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SAN FRANCISCO (AP) -- Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and the San Francisco 49ers amassed a franchise-record 621 yards in blowing by the Buffalo Bills 45-3 on Sunday.
Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.
Rian Lindell kicked a 31-yard field goal in the first quarter before San Francisco scored the final 42 points to hand Buffalo (2-3) its second straight embarrassing loss.
Ryan Fitzpatrick threw for 126 yards and an interception, and the Bills rushed for only 89 yards, most with the game well out of hand once again.